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XELJANZ / XELJANZ XR Drug Interactions (tofacitinib)

7 DRUG INTERACTIONS

Table 6 includes drugs with clinically important drug interactions when administered concomitantly with XELJANZ/XELJANZ XR/XELJANZ Oral Solution and instructions for preventing or managing them.

Table 6: Clinical Relevant Interactions Affecting XELJANZ/XELJANZ XR/XELJANZ Oral Solution When Coadministered with Other Drugs
Strong CP3A4 Inhibitors (e.g., ketoconazole)
Clinical ImpactIncreased exposure to tofacitinib
InterventionDosage adjustment of XELJANZ/XELJANZ XR/XELJANZ Oral Solution is recommended
[see Dosage and Administration (2), Clinical Pharmacology, Figure 3 (12.3)]
Moderate CYP3A4 Inhibitors Coadministered with Strong CYP2C19 Inhibitors (e.g., fluconazole)
Clinical ImpactIncreased exposure to tofacitinib
InterventionDosage adjustment of XELJANZ/XELJANZ XR/XELJANZ Oral Solution is recommended
[see Dosage and Administration (2), Clinical Pharmacology, Figure 3 (12.3)]
Strong CYP3A4 Inducers (e.g., rifampin)
Clinical ImpactDecreased exposure to tofacitinib and may result in loss of or reduced clinical response
InterventionCoadministration with XELJANZ/XELJANZ XR/XELJANZ Oral Solution is not recommended
[see Clinical Pharmacology, Figure 3 (12.3)]
Immunosuppressive Drugs (e.g., azathioprine, tacrolimus, cyclosporine)
Clinical ImpactRisk of added immunosuppression; coadministration with biologic DMARDs or potent immunosuppressants has not been studied in patients with rheumatoid arthritis, psoriatic arthritis, UC, or pcJIA.
InterventionCoadministration with XELJANZ/XELJANZ XR/XELJANZ Oral Solution is not recommended
[see Indications and Usage (1), Clinical Pharmacology, Figure 3 (12.3)]
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