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SILVADENE® CREAM Clinical Pharmacology (silver sulfadiazine)

CLINICAL PHARMACOLOGY

Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. Results from in vitro testing are listed below.

Sufficient data have been obtained to demonstrate that silver sulfadiazine will inhibit bacteria that are resistant to other antimicrobial agents and that the compound is superior to sulfadiazine.

Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect.

Results of In Vitro Testing with SILVADENE® Cream 1% (silver sulfadiazine) Concentration of Silver Sulfadiazine Number of Sensitive Strains/Total Number of Strains Tested
Genus & Species 50 μg/mL 100 μg/mL
Pseudomonas
aeruginosa 130/130 130/130
Xanthomonas (Pseudomonas)
maltophilia 7/7 7/7
Enterobacter species 48/50 50/50
Enterobacter cloacae24/24 24/24
Klebsiella species 53/54 54/54
Escherichia coli63/63 63/63
Serratia species 27/28 28/28
Proteus mirabilis53/53 53/53
Morganella morganii10/10 10/10
Providencia rettgeri2/2 2/2
Providencia species 1/1 1/1
Proteus vulgaris2/2 2/2
Citrobacter species 10/10 10/10
Acinetobacter
calcoaceticus 10/11 11/11
Staphylococcus aureus100/101 100/101
Staphylococcus
epidermidis 51/51 51/51
β-Hemolytic
Streptococcus 4/4 4/4
Enterococcus species 52/53 53/53
Corynebacterium-
diphtheriae 2/2 2/2
Clostridium perfringens0/2 2/2
Candida albicans43/50 50/50

Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.

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