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CYTARABINE, 500 MG/25 ML MULTI-DOSE VIAL U.S. PHYSICIAN PRESCRIBING INFORMATION Overdosage (cytarabine injection)

OVERDOSAGE

There is no antidote for cytarabine overdosage. Doses of 4.5 g/m2 by intravenous infusion over 1 hour every 12 hours for 12 doses has caused an unacceptable increase in irreversible CNS toxicity and death.

Single doses as high as 3 g/m2 have been administered by rapid intravenous infusion without apparent toxicity.

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